Tenof EM

Tenof EM is a nucleoside reverse transcriptase inhibitor; this is involved in treating HIV infection. Tenof EM tablets eliminate the HIV virus from the blood. Tenof EM is not permanent remedy, it does not cure the disease, but it prevents AIDS. Tenof EM is Available in various dosage forms like tablets, capsules and solution form. Tenof EM is not under the conditions like; Pregnancy, Breastfeeding, Allergic conditions, Lactic acidosis, abnormal liver problems, Kidney problems CD 4+ cells are essential for the prevention of invasion of virus into the body. HIV is eradicate the cells and leads to cause vulnerable condition like AIDS. Tenof EM is useful in the treatment of HIV infection, by improving the CD 4+ cells in the body

Emtricitabine and tenofovir disoproxil fumarate

Tenof EM

200mg + 300mg

Hetero





INDICATION

Tenof EM is primarily indicated for; HIV infection Chronic hepatitis B virus infection

Pharmacodynamic

There are two major anti retroviral agents that present in Tenof EM; contains Emtricitabine, tenofovir disoproxil fumarate.

Emtricitabine

This is one of the active ingredients of Tablet Tenof EM , Emtricitabine is a nucleoside analog of cytidine, various cellular enzymes involved in conversion of Emtricitabine into Emtricitabine 5’-triphosphate. This conversion will prohibit the effect of HIV-1 reverse transcriptase. This binds with deoxycytidine 5’ triphosphate, mingled into viral DNA and chain termination of the cells occur.

Tenofovir disoproxil fumarate

Tenof EM → an acyclic nucleoside phosphonate diester analog of adenosine monophosphate. Tenofovir disoproxil fumarate is converted into tenofovir by diester hydrolysis. Tenofovir is phosphorylated into tenofovir diphosphate by cellular enzymes This inhibits the effect of HIV 1 RT by competing with natural substrate (deoxyadenosine 5’-triphosphate), fusing into DNA, by DNA chain termination.




PHARMACOKINETIC

Tenof EM is rapidly absorbed with peak plasma concentration occurring 1-2 hours.

Tenof EM is highly bound to the human plasma protein over the range of 0.02-200 μg/mL (Emtricitabine) and 0.01–25 μg/mL (tenofovir).

Tenof EM is metabolized and its metabolites are released through urine.

Excretion of tablet Tenof EM occurs through urine. The mean plasma termination half-life period of tablet Tenof EM is Emtricitabine 10 hours (7.4-18.0); tenofovir 17 hours (12.0-25.7). The bioavailability of both Emtricitabine is 92% and tenofovir is 25%




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Tenof EM
Brand Tenof EM
Ingredients Emtricitabine and tenofovir disoproxil fumarate
Strength 200mg + 300mg
Manufactured Hetero
Rating


Tenof EM Dosage and administration

Tenof EM ,the dosage prescribed for the treatment of HIV infection; Tenof EM administrated One tablet should be taken as a single dose. Tenof EM is taken orally with or without food

The common effects caused by Tablet Tenof EM

Gastro intestinal

diarrhea, nausea, vomiting

General

injection site reaction, fatigue

Infections

sinusitis, upper respiratory infection, throat infection

Central nervous system

head ache, dizziness, psychiatric disorders, depression, and sleeplessness

Skin

rash

Common effects

Fever, chills Pain during urination Fatigue Chest pain Skin discoloration Numbness, burning or tingling (hands, arm, feet) Itching Muscle stiffness Depression

Adverse effects

Severe Acute Exacerbations of Hepatitis B New Onset or Worsening Renal Impairment. Lactic Acidosis/Severe Hepatomegaly with Steatosis Bone Effects of Tenofovir DF. Immune Reconstitution Syndrome.

Some other effects

Anorexia, Dyspepsia, asthenia, dizziness, fatigue, headache, rash, hypophosphatemia, raised liver enzymes, hepatitis, renal effects (e.g. nephritis, nephrogenic diabetes insipidus, proximal renal tubulopathy, renal failure), bone pain, osteomalacia, muscle weakness, myopathy. Rarely, raised serum amylase levels, pancreatitis, and rhabdomyolysis.


DRUG INTERACTION



  • Coadminstration of tablet Tenof EM with atazanavir, plasma concentration of Tenof EM increased and the plasma concentration of atazanavir decreased.

  • Some of medicines cause drug interactions; Didanosine Ritonavir boosted Lopinavir Nephrotoxicity drugs like; cidofovir, acyclovir, valaciclovir etc



Contraindication

Tenof EM should not be used in persons with unknown or positive 1 status. Tenof EM not used as monotherapy, it is used with other retroviral medicine. Hypersensitivity in lactation



Caution should be taken while using tablet Tenof EM , if patient having Hepatomegaly or other liver problems Renal impairment Pregnant women

The pregnancy category of Tablet Tenof EM is comes under category B Tenof EM should not preferred for pregnant women or become pregnant.

Tenof EM should be stored in a cool place.

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