Thaangio 100mg

Thaangio 100mg is a piperidinyl isoindole basically introduced as a non-barbiturate hypnotic but detached from the market due to teratogenic effects. It has been renewing and indicated for several immunological and inflammatory disorders. Thaangio 100mg displays immunosuppressive and anti-angiogenic activity. It prevents release of tumor necrosis factor-alpha from monocytes and modulates another cytokine action.

Thalidomide

Thaangio

100mg

Dr. Reddy’s




INDICATION

Thaangio 100mg in combination with dexamethasone is indicated for the treatment of patients with newly diagnosed multiple myeloma.
Thaangio 100mg is used for the acute treatment of the cutaneousmanifestations of moderate to severe erythema nodosum leprosum (ENL).
Thaangio 100mg is not used as monotherapy for such ENL treatment in the presence of moderate to severe neuritis.
Thaangio 100mg is also used as maintenance therapy for prohibition and suppression of the cutaneous manifestations of ENL relapsed.

Mechanism of action

The immunologic effects of thalidomide vary considerably under different conditions but may be related to overthrow of exaggerated tumor necrosis factor-alpha (TNF-a) production and down-modulation of selected cell surface adhesion molecules involved in leukocyte migration. For example, patients getting of thalidomide has been resulted to reduce circulating levels of TNF-a in patients with ENL, however, it has also been shown to increase plasma TNF-a levels in HIV-seropositive patients. Since cancer therapy, the drug may work as a VEGF inhibitor.



Pharmacokinetic

Time to peak plasma concentration is 2.9 to 5.7 hours

plasma protein binding is 55% and 66% for the (+) R and (-) S enantiomers, respectively

Metabolized hepatically by enzymes of the cytochrome P450 enzyme system.

Excreted in the urine as unchanged drug is less than 0.7% of the dose. Half-life of thalidomide is 5 to 7 hours.



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drug
Brand Thaangio
Ingredients Thalidomide
Strength 100mg
Manufactured Dr. Reddy’s laboratories
Rating

The dosage recommendation of following condition as follows :
Multiple Myeloma :
The recommended dose is 200mg PO qHS in 28-day cycles
Administer 40 mg of dexamethasone on days 1-4,9-12,17-20 of 28 days.
Erythema Nodosum leprosum :
The initial recommended dose is 100-300 mg PO qHS.
In case of more severe reaction then may initiate at 400mg. continue until active symptoms subsided, at least 2 weeks then titrate down by 50 mg increment q 2-4 weeks.

Side effects

• Teratogenicity
• Venous and arterial thromboembolism
• Increased Mortality
• Drowsiness and somnolence
• Peripheral neuropathy
• Dizziness and orthostatic hypotension
• Neutropenia
• Thrombocytopenia
• Increased HIV viral load
• Bradycardia
• Seizures
• Tumor Lysis
• Hypersensitivity .

Precautions

Prior initiating Thaangio 100mg treatment, make sure to inform doctor about any other medications you are taking (containing prescription, over-the-counter, vitamins, herbal remedies, etc.). Avoid taking aspirin, or products including aspirin until the doctor especially permits this.
Avoid taking regimens that may cause drowsiness without first consulting your health care provider. Also avoid alcohol. For both men and women use contraceptives, and do not conceive a child (get pregnant) while taking Thaangio 100mg. serious, life-threatening birth defects may have reported with even one 50 mg dose. Methods of contraception has two types, such as latex condoms and spermicides, are required.
For women of childbearing potential should use contraception 4 weeks before you can start Thaangio 100mg. The manufacturer needed you to take a pregnancy test every month before you initiate a new prescription of thalidomide. This is to confirm that you or your significant other is not pregnant. Consult with your doctor when you may safely become pregnant or conceive a child after treatment. Do not breast feed while taking this medication.

DRUG – DRUG INTERACTION

  • Concomitant use of Thaangio 100mg with opioids, antihistamines, antipsychotics, anti-anxiety agents, other CNS depressants may lead to additive sedative effect.
  • Interaction of Thaangio 100mg with cardiovascular medication will cause an additive bradycardic effect and should be used with caution.
  • Combination with bortezomib, amiodarone, cisplatin, docetaxel, paclitaxel, vincristine etc will cause peripheral neuropathy and should be used with caution.
  • Unknown condition when concomitant use of hormonal contraceptives further increases the risk of thromboembolism with Thaangio 100mg

Contraindications

Hypersentivity
Pregnancy - the drug cause risk to fetal




Pregnancy category X: Thaangio 100mg may cause risk to fetal when administer to a pregnant woman. This drug should not administer to a pregnant woman or a woman who aims to become pregnant. If a woman becomes pregnant during Thaangio therapy, the drug must be discontinued immediately, and the woman given correct counselling.

There has no data available for the presence of Thaangio 100mg in human milk and effects of drug on breastfed infants. Avoid breastfeeding during treatment with Thaangio 100mg

Store at 20°C to 25°C.
Protect the drug from light.

Take the dose immediately before next dose duration. Next dose time reaches then left off the missed dose and continue regular schedule. Avoid taking double dose at same time. Please consult the doctor for further information.


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