Tolsama 30mg

Tolsama 30mg is an aquaretic drug which functions as a selective, competitivevasopressin receptor 2 (V2) antagonist will prevent hyponatremia (low blood sodium levels) along with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH)
Tolsama 30mg decrease the level of a hormone which manage the balance of water and salt (sodium) in the body. High levels of this hormone can cause an imbalance that causes low sodium levels and fluid retention.

Tolvaptan

Tolsama

30mg

MSN Laboratories




INDICATION

Tolsama 30mg is used for the treatment of clinically important hypervolemic and euvolemic hyponatremia contains patients with heart failure and Syndrome of Inappropriate Antidiuretic Hormone (SIADH).

PHARMACOLOGICAL ACTION

Tolvaptan is a type of selective and competitive arginine vasopressin receptor 2 antagonist. Vasopressin show action on the V2 receptors found in the walls of the vasculature and luminal membranes of renal collecting ducts. By stopping V2 receptors in the renal collecting ducts, aquaporins do not enter themselves into the walls hence inhibiting water absorption. This activity basically results in a rise in urine volume, reduce urine osmolality, and increase electrolyte-free water clearance to decrease intravascular volume and a higher serum sodium level. Tolvaptan is specifically required for heart failure patients as they have higher serum levels of vasopressin.



Pharmacokinetic

Time to peak plasma concentration of Tolsama is 2-4 hours and the absolute bioavailability is unknown. Food will not affect the bioavailability of Tolsama.

The plasma protein bounding of Tolsama is 99% and Volume of distribution in healthy subjects is 3L/kg.

Tolsama is metabolism occurs by CYP3A4 enzyme in the liver.

< 1% is excreted in the urine (unchanged form) and through fecal is very small amount of renal elimination.
In oral dose, half-life of Tolsama is 12 hours




Blueberrypharma.com-img1

medicine
Brand Tolsama
Ingredients Tolvaptan
Strength 30mg
Manufactured MSN Laboratories
Rating

The recommended starting dose for Tolsama is 15 mg administered once daily without food. The dose is increased to 30 mg once daily, after at least 24 hours, to a maximum of 60 mg once daily, as required to achieve the desired level of serum sodium.
Do not administer Tolsama for more than 30 days to minimize the risk of liver injury.
Following discontinuation from Tolsama, advised the patients to resume fluid restriction and should be observed for changes in serum sodium and volume status.
Administration of Tolsama should be without food
Grape juice should be avoided during therapy with Tolsama
Overdose :
Administrating monotherapy oral doses up to 480 mg and multiple doses up to 300 mg once in a day for 5 days have been well accepted in studies in healthy subjects. There is no essential antitoxin for Tolsama intoxication. The signs and symptoms of an acute overdose can be expected to be those of extra pharmacologic effect: a increase in serum sodium concentration, polyuria, thirst, and dehydration/hypovolemia.

Precautions

  • The conditions like Hypernatremia, hypovolemia, and/or dehydration; provoke patient to drink whenever thirsty

  • Risk of potassium level increased

  • Tolsama 15mg produce Osmotic demyelination syndrome is a harm along with too-fast correction of hyponatremia

  • Tolsama 15mg can develops serious and likely fatal liver injury; acute liver failure needed liver transplantation reported; discontinue if laboratory abnormalities or signs or symptoms of liver injury are apparent.

DRUG – DRUG INTERACTION

  • Tolsama 30mg interaction with strong CYP3A4 inhibitors like ketoconazole will have highest labelled dose would be normal to cause an even heavy increase in exposure.

  • Tolsama co administration with moderate CYP3A4 inhibitors will increase in exposure of Tolsama 30mg.

  • When concomitant use treated with P-gp inhibitors will have reductions in the dose of Tolsama 30mg

  • Combination of rifampin and Tolsama 30mg decrease exposure to tolvaptan by 85%.

  • Concomitant use of lovastatin, digoxin, furosemide, and hydrochlorothiazide has no clinically relevant impact on the exposure to Tolsama 30mg

Contraindications

Tolsama 30mg is contraindicated with following condition as • Patients with autosomal dominant polycystic kidney disease because the drug causes severe and possible fatal liver injury. • Required in acutely raised serum sodium • Patients inability to sense • Hypovolemic /hyponatremia



Pregnancy category is C: There are no enough and well tolerated studies of Tolsama 30mg tablets but can be used during pregnancy only if the possible benefits prove the possible risk to the foetus.

Tolsama 30mg excreted in human milk is unknown because most of the drugs are excreted into human milk, due to probable for severe adverse reaction in nursing infants from Tolsama tablets, taking into consideration the Tolsama tablets importance to the mother, a decision should be taken to discontinue breastfed or Tolsama 30mg drug

Store the Tolsama 30mg at 25°C (77°F) exclusively permitted between 15°C and 30°C
Keep away from the children’s reach.

In case the single dose is missed the have the tablet dose immediately before the next dose timing reaches or skip the missed dose and continue the regular schedule.
Avoid having of extra dose at a time. Consult the doctor for further details.

Blueberrypharma.com-img2



Quick Contact




Prescription upload






PRESCRIPTION


Blueberrypharma.com , a fully licensed and regulated pharmacy medicine, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.

Blueberrypharma.com will not dispense any prescription medication without a valid prescription from a licensed physician.

If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.

The drug information provided in the Blueberrypharma.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.

Blueberrypharma.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from Blueberrypharma.com

At Blueberrypharma.com , a Caregiver can order prescription medicines on your behalf.