Trasturel 150mg

Trasturel 150mg is a type of drugs which belongs to anticancer medication. Trasturel 150mg injection consist of a targeted cancer drug known as Transtuzumab, which is pharmacologically classified as humanized monoclonal antibody produced by recombinant DNA technology.
Trasturel 150mg is a prescription drug and to be administered under the guidance of a qualified physician experienced in the use of cancer chemotherapeutic agents.

Trastuzumab

Trasturel

150mg

Reliance Life Sciences





Injection Prescribed for

The injection Trasturel 150mg is indicated alone or combination with other medicine for the treatment in patients who suffering from metastatic breast cancer.
The drug also used with combination of other medicine for the treatment of certain types of stomach or esophagus cancer in some persons.

work as

Various type of breast cancer cells has a greater than normal level of a protein called HER2 (human epidermal growth factor receptor 2) on their surface.
These HER2 receptors will receive signals which stimulate the tumor cells to grow and multiply. But breast cancer cells with too many HER2 receptors can Choice too many growth signals and so initiate developing and replicating too much and too fast.
Trasturel 150mg acts by attach itself to the HER2 receptors on the surface of breast cancer cells and block them from collecting growth signals. By stopping the signals, Trasturel 150mg can slow or prohibit the growth of the breast cancer and the drug is an immune targeted therapy. In addition to inhibiting HER2 receptors, Trastuzumab can also help to fight against breast cancer by attentive the immune system to damage the cancer cells onto which it is attached.


drug
Brand Trasturel
Ingredients Trastuzumab
Strength 150mg
Manufactured Reliance Life Sciences
Rating


Dosage and administration

The Trasturel injection should not combine with other drugs and do not administer as an intravenous push or bolus. Trastuzumab should not be give alternative for or with ado-Trastuzumab emtansine
Adjuvant treatment, breast cancer: The drug given according to one of the following doses and schedules for a 52 weeks total of trastuzumab treatment:

During combination with paclitaxel, docetaxel, or docetaxel /Carboplatin

Initiating dose of 4 mg/kg as an IV (intravenous infusion) over 90 minutes followed at 2 mg/kg as an IV(intravenous infusion) over 30 minutes weekly during treatment of chemotherapy given with paclitaxel or docetaxel for first 12 weeks or 18 weeks (docetaxel/carboplatin) The Trasturel dose for One week following the last weekly administers Trastuzumab at 6 mg/kg as an IV (intravenous infusion) over 30 to 90 minutes every three weeks.
The injection given as a single agent within three weeks following completion of multi-modality, anthracycline-based chemotherapy regimens: For an intravenous infusion over 90 minutes: Initial dose at 8 mg/kg
Successive doses at 6 mg/kg over 30 to 90 minutes every three weeks as an intravenous infusion.
Adjuvant treatment stretching beyond one year is not recommended.

Metastatic Treatment, Breast Cancer

Trasturel given treatment alone or in combination with paclitaxel, at a starting dose of 4 mg/kg as a 90-minute intravenous infusion continued by successive once weekly doses of 2 mg/kg as 30-minute intravenous infusions until disease development.

Metastatic Gastric Cancer

Trasturel administrated at a starting dose of 8 mg/kg as a 90-minute IV intravenous infusion continued by successive doses of 6 mg/kg as an intravenous infusion over 30 to 90 minutes every three weeks until disease development.

Common side effects

Redness at injection site (IV) Muscle/joint/back pain Insomnia Tiredness Mild skin rash Stuffy nose Sinus pain

Serious side effects

Increased coughing Sudden unexplained weight gain Unusual tiredness Easy bruising or bleeding Fast or pounding heartbeat Increased coughing

Embryo fetal damage

Trasturel 150mg is contraindicated to pregnancy period. Do not becoming conceive during this therapy. Use efficient contraceptives during treatment

Cardiomyopathy

Patient taking Trasturel 150mg injection have high risk of exposing to cardiac disorders. Provide alternative therapy management In serious condition, treatment should be discontinuing

Pulmonary toxicity

Some serious fatal cases of pulmonary toxicity occur during Trasturel 150mg treatment.

Infusion reactions

During Trasturel 150mg treatment some life-threatening infusion reactions are produced. In serious infusion reactions, Stop the Trasturel 150mg treatment permanently. Patient should be treated with premedication before starting the infusion to overcome the such problem, During Trasturel 150mg treatment. Use with Caution.

Therapy induced neutropenia

Higher incidence of neutropenia occurs during Trasturel 150mg treatment.


Drug- drug interaction



  • In some cases, patient should get anthracycline, in that situation patient’s cardiac function should be checked carefully with regular intervals.
  • Avoid taking take anthracycline treatment for 7 months after stopping the Trasturel 150mg treatment.
  • Trasturel 150mg interaction with anthracycline after ending of Trasturel 150mg treatment may have a chance of getting cardiac problem. This side effects occur because of Trastuzumab have high disaster period is based on population PK analysis.


Contraindications

No Possibility of contraindicated occurs. The patients are contraindicated to the component present in the Trasturel 150mg, Hence Hypersensitivity reactions are occurring.




During pregnancy this cancer medicine may be harmful for your baby. So, if this drug is used during pregnancy, or if the patient becomes pregnant while taking this medicine, the patient should be advice about the hidden hazard to a fetus. You should tell about your pregnancy to your doctor. Your pharmacist must understand your condition to check your health, and then your baby will be protected from infection soon after birth. You can also discuss with your doctor about birth control methods that will work for you.

While using Trasturel 150mg passes into breast milk or if it could affect a nursing baby. Hence breast feeding is not recommended while on treatment with Trasturel 150mg.

Store the drug at 2°C to 8°C (refrigerator temperature) Protected the carton away from heat & light Stored at 2°C to 8°C for 28 days after reconstitution Stored Trasturel 150mg diluted bag at 2°C to 8°C for 24 hours.

It is important to accept each scheduled dose of Trastuzumab medication as instructed. If you miss a dose, leave the missed dose and continue with your regular dosing schedule. Do not make up for a missed one. If you are not sure about what to do after missing a dose, the take advice with doctor or pharmacist.




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