Valcivir 1000mg

Valcivir 1000mg , is an antiviral drug used in the management of herpes simplex, herpes zoster(shingles), and herpes B. It is a prodrug, which is converted to acyclovir in a person’s body. Valcivir 1000mg was approved for medical use in 1995.[1] . Valcivir 1000mg has been available as a generic drug in the U.S. since November 25, 2009 Valcivir 1000mg involves an active composition like valacyclovir that are pharmacologically classified as nucleoside analogue of viral DNA polymerase prohibitor.





Valcivir indicated for

Varicella zoster virus (VZV) infections – herpes zoster
Valcivir 1000mg tablets are used to treat of herpes zoster (shingles) and ophthalmic zoster in immunocompetent adults. Valaciclovir tablets are used to treat of herpes zoster in adult patients with mild or moderate immunosuppression.

Herpes simplex virus (HSV) infections
Valaciclovir tablets are necessary for the treatment and suppression of HSV infections of the skin and mucous membranes including In immunocompetent adults and adolescents and in immunocompromised adults the Valcivir indicated for first episode of genital herpes Indicated for recurrences of genital herpes in immunocompetent adults and adolescents and in immunocompromised adults Suppression of recurrent genital herpes in immunocompetent adults and adolescents and in immunocompromised adults. treatment and suppression of recurrent ocular HSV infections

Cytomegalovirus (CMV) infections:
Valaciclovir tablets are indicated for the prophylaxis of CMV infection and disease following solid organ transplantation in adults and adolescents


Valacyclovir is a prodrug which is go through phosphorylation by using viral thymidine kinase enzyme for convert of acyclovir triphosphate, an active metabolite. This active molecule is included in the prohibition of herpes viral DNA replication by aggressive prohibition of viral DNA polymerase.

After infusion of this metabolite into the virus & leads to terminate the developing viral DNA chain. Valacyclovir consist of; Block the DNA synthesis Destabilizing the strand Prevention of new viral growth

ADME properties

After Valcivir 1000mg oral intake , valacyclovir is fastly absorbed from the gastrointestinal tract and exhibit oral bioavailability by 54.5% plus or minus 9.1%.

The Valcivir 1000mg has human plasma protein binding capacity is 13 to 18%.

Valacyclovir is hastily absorbed and approximately 99% of drug get convinced into an active form like acyclovir & L-valine by sustain first pass metabolism & hepatic metabolism by enzymatic hydrolysis.

Radioactivity gets eliminated via urine is nearly 89%. The mean half life period of valacyclovir is 2.5 to 3.3 hours.

Valcivir 1000mg
Brand Valcivir
Ingredients valacyclovir
Strength 1000mg
Manufactured Cipla


Valcivir tablet should be administered with or without food.

In adults

Cold sore (herpes labialis):
The prescribed dose of Valcivir is 2 gram should be taken for two times a day for one day in 12 hours apart.

Genital herpes (initial episode):
The prescribed dose of Valcivir is 1 grams should be taken as twice daily for 10 days.

Recurrent episode:
The prescribed dose is 500mg should be administered orally as twice daily for 3 days.

Suppressive treatment:
In ceaseless suppressive treatment, the recommended measurements are 1 gram taken as once every day in patients with typical capacities. In patients with 9 repeats for every year, the recommended dosage is 500mg ought to be regulated as once day by day.

In HIV-1 infected patients:
500mg of Valcivir should be administered orally as two times a day.

Reduction of transmission:
500mg of Valcivir should be taken as once daily.

Herpes zoster:
In this condition, the recommended dose of Valcivir is 1gm should be taen as three times a Day for 7 days.

In pediatrics

Cold sores (herpes labialis):
The patient’s age of greater or equal to 12 years, the recommended dose of Valcivir is 2 gram should be taken as twice daily for 1 day.

Chicken pox
20mg/kg of Valcivir should be administered orally as three times a day for 5 days. The maximum dose per day is not exceeding 1 gram 3times a day.

The common side effects

Anemia, Increased AST, Neutropenia, Respiratory tract infection, Decreased platelet counts, Nasopharyngitis, Headache, Dizziness, Nausea, Abdominal pain

The major adverse effects of Valcivir 1000mg are

Thrombotic thrombocytopenia purpura / hemolytic uremic syndrome, Acute renal failure, Central nervous effects

Central nervous system effects

In pediatric patients with or without renal impairment should be describe with nervous problems like agitation, hallucination, confusion, seizures while on treatment with Valcivir 1000mg . In this condition treatment should be stopped.


This circumstances occurs during the treatment using with Valcivir 1000mg , this may causes death with chronic HIV-1 disease & bone marrow transplant. In this lethal condition therapy should be immediately stopped & monitor the indication due to this fetal case.

Acute renal failure

Use Valcivir 1000mg in geriatric patients very cautiously. Dosage reduction should be necessary for renal impaired patients. Patients who are getting nephrotoxic drugs should be taken care while administration of Valcivir 1000mg tablets. Patients have no enough hydration may causes precipitation of acyclovir in renal tubules.


No drug- drug interactions occurs in the valacyclovir therapy.

Valcivir 1000mg is highly contraindicated in patients with hypersensitivity reactions due to patients are contraindicated to the ingredients of Valcivir 1000mg.

The pregnancy category of valacyclovir is B It should be used with caution. Caution should be taken while administering Valcivir 1000mg to nursing woman.

The drug stored at temperature of 15°C to 25°C. Protect the drug away from moisture, heat & light.

Missed dose condition should be avoided by maintain the regular dosing schedule. Do not skip the dose. Avoid self medication. If you missed dose, patient should be get advice from the medical practitioner & follow the instructions.

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