Viroclear contains an anti-viral agent known as sofosbuvir Viroclear is a single fixed dose combination of two nonstructural protein inhibitors like NS5B. Sofosbuvir is used with other antiviral drugs to prevent hepatitis c viral infection. Viroclear is a prescription drug used under the supervision of medical practioners





Viroclear therapeutic indication

Viroclear is used for the treatment of chronic hepatitis C viral infection. In decompensated cirrhosis, Viroclear tablets are combined with ribavirin The major limitation of use during Viroclear therapy;

In hepatitis C viral genotype III infected patients with cirrhosis getting Daclatasvir in combination with sofosbuvir for 12 weeks leads to cause reduction of sustained virological response rate frequently.

Viroclear mechanism of action

Viroclear – Sofosbuvir

Sofosbuvir is pharmacologically categorized as uridine monophosphate analogue prohibitor of HCV polymerase.

The mechanism of action of sofosbuvir is basically involved in RNA replicates inhibitor.

Sofosbuvir is available as prodrug which gets converted into an active uridine triphosphate and inserted the active moiety into viral RNA by NS5B polymerase enzyme causes chain elimination.

Viroclear ADME properties

The peak plasma concentration time of sofosbuvir is 0.5 to 1 hour

Sofosbuvir plasma protein binding capacity 61 to 65%

The metabolism of both Viroclear is occurs hepatically Sofosbuvir: cathepsin A, carboxyl esterase 1 or HINT1

Sofosbuvir half life is 0.4 hour & GS-331007: 27 hours Sofosbuvir: 80% through urine, 14% through feces.

Brand Viroclear
Ingredients Sofosbuvir
Strength 400mg
Manufactured Abbott

The usual dosage of Viroclear by combination with other medicines; Patient obtained with genotype I, IV, V or VI chronic hepatitis C viral infection: Viroclear is combined with ribavirin and peg interferon alfa should be taken as a single dose for 12 weeks Viroclear and ribavirin should be taken in case of patients are undesirable to take peg interferon alfa for 24 weeks

Patients suffered with genotype II chronic hepatitis C:
Viroclear should be combined with ribavirin as a single dose for 12 weeks

Patients with genotype III hepatitis:
Viroclear combined with ribavirin and peg interferon alfa and it should be taken as a single dose for 12 weeks Otherwise Viroclear with ribavirin should be taken as single dose for 24 weeks

In liver transplantation:
Viroclear should be concurrently used with ribavirin as a single dose until liver transmission.

In pediatric:

Viroclear tablet is recommended for the children at age 12 or weight of at least 35kg; In without cirrhosis or with child Pugh A or compensated: The recommended dosage is one tablet of Viroclear should be combined with weight-based ribavirin as a single dose for 12 weeks

In decompensated cirrhosis:
The prescribed dosage of Viroclear is one tablet should be used with ribavirin for 24 weeks

Ribavirin dosage:
Ribavirin is prescribed to consume in two divided doses only with food Initial dose 600mg slowly increased up to 100mg per day in weight less than 75kg 1200mg should be taken per day with the weight at least 75kg

In pediatric ribavirin dosage;
<47kg: 15mg/kg/day 47 to 49kg: 600mg/day 50 to 65kg: 800mg/day 66 to 80kg: 1000mg/day >80kg: 1200mg/day No dosage adjustment is followed in the therapy using Viroclear in case of renal and hepatic impairment.


GenerallyViroclear is administered with or without food. Viroclear is taken as a single dose The patients should give tablet by crushing or chewing the tablet, swallow the tablet as whole with some water

Over dosage

No specific antidote is required for over dosage of sofosbuvir. In case of over dosage, patient should be provided with general supportive management. Manifestation due to over dosage condition should be monitored. Over dosage should be treated by undergoing hemodialysis.

Viroclear adverse effects

Symptomatic bradycardia while combining with amiodarone Headache, Fatigue, Anemia, Increased AST, ALT, Increased bilirubin, Increased lipase, Nausea, Diarrhea, Insomnia, Dizziness, Somnolence

Risk of HBV reactivation

This fatal case is occurs in the patient who is receiving anti-HCV therapy. Prevent the problem by measuring HBsAg & anti-HBc levels of patients before starting the treatment. Hepatic function test should be monitored frequently and maintain the hepatic enzymes. Initiate the HBV infection management for the patients.

Loss of virological response

Due to advancement of resistance of Daclatasvir it should be combined with other abnti-viarl agents like sofosbuvir for better activity.


Avoid concurrent use of Viroclear with amiodarone Monitor the ECG Provide alternative medication for reducing the cardiac issues Counsel the patients before initiate the therapy about the risk associated with these combination.

Risk related to ribavirin

Ribavirin is contraindicated to pregnancy because it causes fetal harm even to death.

Combination of P-gp inducers

The combination of Viroclear with P-gp inducers causes loss of activity by decreasing the sofosbuvir concentration.

Viroclear drug interactions

  • Viroclear is a substrate of P-gp& BCRP transporters. While using Viroclear with P-gp or BCRP strong inducers like rifampin or st Johns wort may causes decreasing the plasma concentration of sofosbuvir. Thus the results depletion of therapeutic effect of Viroclear
  • Viroclear co administration with P-gp or BCRP inhibitors, causes increasing the plasma concentration of Viroclear
  • Viroclear with analeptic drug like modafinil causes decreasing the effect of concentration of Viroclear.
  • While combining with Viroclear with amiodarone, no effect of concentration occurs but symptomatic bradycardia occurs
  • Viroclear with vitamin K antagonist, fluctuate the effect of vitamin K antagonist
  • Viroclear with anticonvulsants like phenytoin, Phenobarbital or carbamazepine causes decreasing the effect of Viroclear
  • Viroclear with anti-mycobacterials causes depletion in effect of concentration of Viroclear


Viroclear is contraindicated to; Pregnancy while combined with ribavirin. Combination of Viroclear with P-gp inducers is contraindicated.

Hypersensitivity reactions are produced while patients are contraindicated to ingredients of Viroclear tablets.

Viroclear uses in

Viroclear pregnancy category; Sofosbuvir: B Ribavirin: X The combination of Viroclear with ribavirin should not be suggested in pregnancy condition because the combination will harm the fetal.

Breast feeding should not be recommended.

In case of patients missed to take the dose of drug, should be consult with medical practitioner & follow the dose immediately. Or Prevent the missed dose by continuing the regular dosing schedule. Avoid self medication

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