Abiraterone is sold under brand name Xbira , it is a one of the chemo medicine. It is an androgen biosynthesis inhibitor useful for the treatment of prostate cancer. It is precisely indicated for use in conviction with castration and prednisolone for the therapy of metastatic castration resistant prostate cancer. Xbira acetate is involved in hormone therapy. It is an adrenal inhibitor.
Usage Of Xbira
Xbira is an inhibitor of CYP17 which is used to treats the patients with metastatic castration-resistant prostate cancer,
The patienthas received earlier chemotherapy with docetaxel combination with prednisone and in failure of androgen deprivation treatment.
The patient clinically not used for chemotherapy with prednisone or prednisolone will preferred treatment with metastatic CRPC in adult men.
Mechanism of action
Abiraterone works by decreasing the testosterone hormone in body. Testosterone is essential for growth of cancer cells in men.
Abiraterone acetate converted to Abiraterone (androgen biosynthesis inhibitor) in vivo.
Prohibits 17α-hydroxylase C 17, 20-lyase (CYP17) Enzyme expressed in testicular, adrenal, prostatic tumor tissues required for androgen synthesis.
Time to high plasma concentration of Xbira tablet takes 12 hours.
Maximum bound to the human plasma protein like albumin and alpha-1 acid glycoprotein.
The main two metabolites of Abiraterone in human plasma are Abiraterone sulphate and N-oxide Abiraterone sulphate.
The drug mainly excreted in 88% feces and 5% in urine Half-life of tablet Xbira is 12 ± 5 hours.
It is a pill taking as 4 tablets once a day, prednisolone reduce the risk of side effects due to Abiraterone.
Prednisolone taken twice daily
It should be taken without food empty stomach (either 2hrs after a meal or 1hr before a meal).
It should be taken at almost the same time every day. Prednisolone is a steroid medication, taken along with Abiraterone for hormonal balance. It should be administered under the supervision of medical oncologist.
Side Effects occurred in Xbira tablets
Generally, all chemo medicine has several side effects and adverse.
Common side effects
Fatigue, Arthralgia, Hypertension, Nausea, edema, Hypokalemia, Diarrhea, vomiting, Cough, headache, Glucocorticoid deficiency, Mineral corticoid deficiency, Hepatotoxicity. Abiraterone acetate is a anti androgen medication, thereby it inhibits the generation of androgens like testosterone and dihydroestosterone in the body.
Major effects occurred in greater than 30% of patient
Retention of fluid, Increase in triglycerides level, Increased the levels of liver enzymes
Less common effects
Swelling of joints and discomfort, Potassium level decreased in blood stream, Peripheral edema, Phosphorus level decreased in blood flow, Diarrhea, UTI
Safety And Warning Of Xbira
Consult the medical practitioner in case of patient experience with following manifestations; Body temperature increases to 100.4°F (38°C or higher, chills). Chest pain Difficulty in breathing Incompetence of urination
Other syndromes, it should be noticed within 24hrs
Dizziness, headache, unusual bleeding, black stools, fatigue, yellowing color of skin and eye, Elevation of blood pressure
It should not give to pregnancy and lactation women. It comes under pregnancy category X (cause fetal harm). In men, drug is excreted in semen; birth control should be used during treatment.